Butovsky believes xenon has potential as an AD treatment. A Phase 1 clinical trial of xenon at BWH is recruiting healthy elderly volunteers to test safety and effects on immune cells. “I hope this ...

Atlas Overview. A survey of regulatory RNA used two cohorts (A), six brain regions (B), and four AD traits (D) to examine four types of RNA (C), turning up more than 25,000 differences between AD and ...

HSV-1 is a common virus. During infection, its DNA incorporates into host chromosomes, where it lies dormant. An estimated two-thirds of adults worldwide carry these latent HSV-1 genes. Previous work ...

Mutations in NPC1 cause Niemann-Pick Type C. Mice lacking NPC1 only in microglia have rampant neuroinflammation and impaired ...

Some drugs can activate AMPK, most prominently metformin, which is approved for diabetes and being trialed in dementia. Less well-known is aldometanib, developed by Lin’s team, which blocks aldolase, ...

A growing body of work implicates infections as a risk factor for Alzheimer’s disease. In the December 19 Alzheimer’s & Dementia, scientists led by Benjamin Readhead at Arizona State University, Tempe ...

A single-center pilot study at the Veterans Affairs Hospital/University of Washington in Seattle reported improved verbal memory retention and attention after a three-week test of 20 international ...

Notably, this coupling crumbles with age in mice. Restoring it not only bolstered neuronal energy reserves, but also strengthened synaptic signaling and counteracted memory loss in old animals.